Cyclohexanemethylamine → HCID 178511588, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of trans-N1-(6-fluoro-2,4′-bipyridin-2′-yl)cyclohexane-1,4-diamine (15 mg, 0.052 mmol), DMSO (0.4 ml), and cyclohexylmethanamine (59.3 mg, 0.524 mmol) was heated at about 105° C. for about 24 hours, or until the product pormation was completed, as indicated by LCMS. The excess amine was removed under reduced pressure to yield a residue. The residue was mixed with 0.5 ml of DMSO, filtered and purified by prep LC. After lyophilization, 11.3 mg of the title compound was obtained as a TFA salt. LCMS (m/z): 380.3 (MH+), retention time=0.61 min. 1H NMR (400 MHz, METHANOL-d4, 45° C.) δ ppm 0.97-1.11 (m, 2 H) 1.17-1.36 (m, 3 H) 1.49-1.72 (m, 6 H) 1.71-1.80 (m, 2 H) 1.84 (d, J=12.91 Hz, 2 H) 2.11-2.28 (m, 4 H) 3.13-3.25 (m, 1 H) 3.28 (d, 2 H, App.) 3.65-3.75 (m, 1 H) 6.65 (d, J=8.61 Hz, 1 H) 7.16 (d, J=7.43 Hz, 1 H) 7.43-7.48 (m, 1 H) 7.52 (t, J=7.83 Hz, 1 H) 7.64 (s, 1 H) 7.85 (d, J=7.04 Hz, 1 H)

Provenance & Evidence