反应详情

A mixture of tert-butyl 4-(5′-chloro-6-(3-fluorobenzylamino)-2,4′-bipyridin-2′-yl-amino)piperidine-1-carboxylate (220 mg, 0.430 mmol), HCl 4M in Dioxane (7 mL, 28.0 mmol) was stirred at ambient temperature for 1 hr. The solvent was evaporated under reduced pressure to yield a solid which was furthe dried under high vacuum to yield 250 mg of the title compound as a HCl salt. A portion of the title compound was purified by prep LC, and then lyophilized to yield 19.0 mg of the title compound as a TFA salt. LCMS (m/z): 412.2 (MH+), retention time=0.60 min.; 1H NMR (300 MHz, METHANOL-d4, 25° C.) δ ppm 1.66-1.83 (m, 2 H) 2.25 (dd, J=14.21, 3.08 Hz, 2 H) 3.08-3.21 (m, 2 H) 3.36-3.51 (m, 2 H) 3.96-4.12 (m, 1 H) 4.65 (s, 2 H) 6.74 (s, 1 H) 6.91 (s, 1 H) 6.94 (s, 1 H) 6.98-7.06 (m, 1 H) 7.12 (d, J=9.96 Hz, 1 H) 7.19 (d, J=7.62 Hz, 1 H) 7.31-7.43 (m, 1 H) 7.77-7.85 (m, 1 H) 8.09 (s, 1 H)

1. customThe solvent was evaporated under reduced pressure
2. customto yield a solid which
3. customwas furthe dried under high vacuum