反应详情

5.0 g (22.5 mmol) of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-fluorobenzene, 1.87 mL (15 mmol) of 5-bromo-2-methylaniline, 1.73 g (1.5 mmol) of tetrakis(triphenyl phosphine)palladium (0), and 7.33 g (15 mmol) of cesium carbonate were heated under reflux for 8 hours in 150 mL of THF. After completion of the reaction, THF was distilled off under reduced pressure, and ethyl acetate was added to separate the solid by filtration. The organic layer was then washed with a saturated sodium chloride solution, and dried over anhydrous sodium sulfate. Thereafter, the solvent was distilled off under reduced pressure. The resulting crude product was separated and purified using silica gel column chromatography, thereby giving 4′-fluoro-4-methylbiphenyl-3-amine (yield: 43%).

1. distillationwas distilled off under reduced pressure, and ethyl acetate
2. additionwas added
3. customto separate the solid
4. filtrationby filtration
5. washThe organic layer was then washed with a saturated sodium chloride solution
6. dry with materialdried over anhydrous sodium sulfate
7. distillationThereafter, the solvent was distilled off under reduced pressure
8. customThe resulting crude product was separated
9. custompurified