3,5-Dimethylphenylboronic acid → 3',4,5'-Trimethylbiphenyl-3-amine

HRID 1963988Notes

Reaction equation

HRID 1963988 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([CH3:9])=[C:6]([CH:8]=1)[NH2:7].[CH3:10][C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[C:15]([CH3:17])[CH:16]=1>>[CH3:10][C:11]1[CH:12]=[C:13]([C:2]2[CH:3]=[CH:4][C:5]([CH3:9])=[C:6]([NH2:7])[CH:8]=2)[CH:14]=[C:15]([CH3:17])[CH:16]=1

Participants

3

Reactant 2

HCID 27343493,5-Dimethylphenylboronic acidHCID 27348055-Bromo-o-toluidine

Product 1

HCID 610252723',4,5'-Trimethylbiphenyl-3-amineYield 94%

Procedure

Using the same method as in Example 5-(i), 5-bromo-2-methylaniline was reacted with 3,5-dimethylphenyl boronic acid to give 3′,4,5′-trimethylbiphenyl-3-amine (yield: 94%).

Sources & evidence

ORD record
ord-adeac1ca811346deb7ac10881e27222b
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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