Cyclododecanamine → 5-Chloro-2-(([2-(cyclododecylamino)-2-oxoethoxy]acetyl)amino)benzoic acid

HRID 1963994Notes

Reaction equation

[CH:1]1([NH2:13])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:29])[CH2:23][O:24][CH2:25][C:26](O)=[O:27])=[C:17]([C:30]([O:32]C)=[O:31])[CH:16]=1>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:29])[CH2:23][O:24][CH2:25][C:26]([NH:13][CH:1]2[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[O:27])=[C:17]([CH:16]=1)[C:30]([OH:32])=[O:31]

Participants

Reactant 2

HCID 2897Cyclododecanamine

HCID 510399542-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid

Product 1

HCID 442510825-Chloro-2-(([2-(cyclododecylamino)-2-oxoethoxy]acetyl)amino)benzoic acid

Procedure

Using the same method as in Example 1-(ii), cyclododecylamine was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 5-chloro-2-(([2-(cyclododecylamino)-2-oxoethoxy]acetyl)amino)benzoic acid.methyl ester (yield: 92%).

Sources & evidence

ORD record: ord-8c3324502fed4c7a8f4a841b3a2797e0
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08415479B2

Reaction notes

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