HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Fluoro(1,1'-biphenyl)-3-amine → 5-Chloro-2-([((2-[(4'-fluorobiphenyl-3-yl)amino]-2-oxoethyl)sulfanyl)acetyl]amino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Fluoro(1,1'-biphenyl)-3-amine | HCID 2782680 | — |
| Reactant | [(2-([4-Chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethyl)sulfanyl]acetic acid | HCID 51040153 | — |
| Product | 5-Chloro-2-([((2-[(4'-fluorobiphenyl-3-yl)amino]-2-oxoethyl)sulfanyl)acetyl]amino)benzoic acid | HCID 66877411 | — |
Reaction Steps
Using the same method as in Example 1-(ii), 4′-fluorobiphenyl-3-amine was reacted with the [(2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethyl)sulfanyl]acetic acid to give 5-chloro-2-([((2-[(4′-fluorobiphenyl-3-yl)amino]-2-oxoethyl)sulfanyl)acetyl]amino)benzoic acid.methyl ester (yield: 78%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415479B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-41bdbf6016b34de2a1a8b8dfa693ec3f |
| Source note | uspto-grants-2013_04 |