3-(2-Pyridyl)aniline → HCID 44251153, compound

HRID 1964000Notes

Reaction equation

HRID 1964000 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[C:9]([CH:11]=[CH:12][CH:13]=1)[NH2:10].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:29])[CH2:23][O:24][CH2:25][C:26](O)=[O:27])=[C:17]([C:30]([O:32]C)=[O:31])[CH:16]=1>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:29])[CH2:23][O:24][CH2:25][C:26](=[O:27])[NH:10][C:9]2[CH:11]=[CH:12][CH:13]=[C:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)[CH:8]=2)=[C:17]([CH:16]=1)[C:30]([OH:32])=[O:31]

Participants

3

Reactant 2

HCID 4595173-(2-Pyridyl)anilineHCID 510399542-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid

Product 1

HCID 44251153HCID 44251153, compound

Procedure

Using the same method as in Example 1-(ii), 3-(pyridin-2-yl)aniline was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 5-chloro-2-([(2-oxo-2-([3-(pyridin-2-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid.methyl ester (yield: 79%).

Sources & evidence

ORD record
ord-769ef241b45f490d84eef401dba6fb12
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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