4-Fluorophenylboronic acid → HCID 66877233, compound

HRID 1964002Notes

Reaction equation

HRID 1964002 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.Br[C:12]1[CH:13]=[CH:14][C:15]([CH3:23])=[C:16]([CH:22]=1)[NH:17][CH2:18][CH:19]([CH3:21])[CH3:20]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:12]2[CH:13]=[CH:14][C:15]([CH3:23])=[C:16]([NH:17][CH2:18][CH:19]([CH3:21])[CH3:20])[CH:22]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 43729495HCID 43729495, compound

Product 1

HCID 66877233HCID 66877233, compoundYield 83%

Procedure

Using the same method as in Example 19-(ii), 4-fluoro-benzene boronic acid was reacted with 5-bromo-2-methyl-N-(2-methylpropyl)aniline to give 4′-fluoro-4-methyl-N-(2-methylpropyl)biphenyl-3-amine (yield: 83%).

Sources & evidence

ORD record
ord-5383c83bd8d340ad851cac6cb637761b
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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