[(2-([4-Chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethyl)sulfanyl]acetic acid → 5-Chloro-2-([((2-oxo-2-[(3',4,5'-trimethylbiphenyl-3-yl)amino]ethyl)sulfanyl)acetyl]amino)benzoic acid

Participants

Reaction Steps

Using the same method as in Example 1-(ii), 3′,4,5′-trimethylbiphenyl-3-amine was reacted with the [(2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethyl)sulfanyl]acetic acid obtained in Example 12-(i) to give 5-chloro-2-([((2-oxo-2-[(3′,4,5′-trimethylbiphenyl-3-yl)amino]ethyl)sulfanyl)acetyl]amino)benzoic acid.methyl ester (yield: 87%).

Provenance & Evidence