3-(4-Pyridyl)aniline → HCID 44250691, compound

HRID 1964004Notes

Reaction equation

HRID 1964004 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:8]=[C:9]([CH:11]=[CH:12][CH:13]=2)[NH2:10])=[CH:3][CH:2]=1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:29])[CH2:23][S:24][CH2:25][C:26](O)=[O:27])=[C:17]([C:30]([O:32]C)=[O:31])[CH:16]=1>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:29])[CH2:23][S:24][CH2:25][C:26](=[O:27])[NH:10][C:9]2[CH:11]=[CH:12][CH:13]=[C:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)[CH:8]=2)=[C:17]([CH:16]=1)[C:30]([OH:32])=[O:31]

Participants

3

Reactant 2

HCID 4595233-(4-Pyridyl)anilineHCID 51040153[(2-([4-Chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethyl)sulfanyl]acetic acid

Product 1

HCID 44250691HCID 44250691, compound

Procedure

Using the same method as in Example 1-(ii), 3-(pyridin-4-yl)aniline was reacted with the [(2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethyl)sulfanyl]acetic acid obtained in Example 12-(i) to give 5-chloro-2-(([(2-oxo-2-([3-(pyridin-4-yl)phenyl]amino)ethyl)sulfanyl]acetyl)amino)benzoic acid.methyl ester (yield: 74%).

Sources & evidence

ORD record
ord-2d27e7887ee542fa871d4b91bff33fee
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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