HuagongsheHuagongshe Chemistry Print Report · For research reference only
[(2-([4-Chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethyl)sulfanyl]acetic acid → 5-Chloro-2-([((2-[ethyl(4'-fluoro-4-methylbiphenyl-3-yl)amino]-2-oxoethyl)sulfanyl)acetyl]amino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [(2-([4-Chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethyl)sulfanyl]acetic acid | HCID 51040153 | — |
| Reactant | N-ethyl-4'-fluoro-4-methylbiphenyl-3-amine | HCID 66877450 | — |
| Product | 5-Chloro-2-([((2-[ethyl(4'-fluoro-4-methylbiphenyl-3-yl)amino]-2-oxoethyl)sulfanyl)acetyl]amino)benzoic acid | HCID 66877177 | — |
Reaction Steps
Using the same method as in Example 15-(i), N-ethyl-4′-fluoro-4-methylbiphenyl-3-amine was reacted with the [(2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethyl)sulfanyl]acetic acid obtained in Example 12-(i) to give 5-chloro-2-([((2-[ethyl(4′-fluoro-4-methylbiphenyl-3-yl)amino]-2-oxoethyl)sulfanyl)acetyl]amino)benzoic acid.methyl ester (yield: 28%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415479B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-cb325b6c33af41c386c137f1135ed0d9 |
| Source note | uspto-grants-2013_04 |