5-Bromo-o-toluidine → HCID 86653350, compound

HRID 1964019Notes

Reaction equation

HRID 1964019 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:9])=[C:6]([CH:8]=1)[NH2:7].[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:25])[CH2:19][O:20][CH2:21][C:22](O)=[O:23])=[C:13]([C:26]([O:28]C)=[O:27])[CH:12]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:9])=[C:6]([NH:7][C:22](=[O:23])[CH2:21][O:20][CH2:19][C:18]([NH:17][C:14]2[CH:15]=[CH:16][C:11]([Cl:10])=[CH:12][C:13]=2[C:26]([OH:28])=[O:27])=[O:25])[CH:8]=1

Participants

3

Reactant 2

HCID 27348055-Bromo-o-toluidineHCID 510399542-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid

Product 1

HCID 86653350HCID 86653350, compound

Procedure

Using the same method as in Example 15-(i), 5-bromo-2-methylaniline was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 2-[((2-[(5-bromo-2-methylphenyl)amino]-2-oxoethoxy)acetyl)amino]-5-chlorobenzoic acid.methyl ester (yield: 92%).

Sources & evidence

ORD record
ord-264d85bd80c844c58473791a764ea05b
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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