2-Methoxyphenylboronic acid → HCID 44251301, compound

HRID 1964020Notes

Reaction equation

HRID 1964020 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1B(O)O.Br[C:13]1[CH:14]=[CH:15][C:16]([CH3:38])=[C:17]([NH:19][C:20](=[O:37])[CH2:21][O:22][CH2:23][C:24]([NH:26][C:27]2[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][C:28]=2[C:29]([OH:31])=[O:30])=[O:25])[CH:18]=1>>[Cl:36][C:33]1[CH:34]=[CH:35][C:27]([NH:26][C:24](=[O:25])[CH2:23][O:22][CH2:21][C:20]([NH:19][C:17]2[CH:18]=[C:13]([C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[O:2][CH3:1])[CH:14]=[CH:15][C:16]=2[CH3:38])=[O:37])=[C:28]([CH:32]=1)[C:29]([OH:31])=[O:30]

Participants

3

Reactant 2

HCID 27339582-Methoxyphenylboronic acidHCID 86653350HCID 86653350, compound

Product 1

HCID 44251301HCID 44251301, compound

Procedure

Using the same method as in Example 19-(ii), 2-methoxybenzene boronic acid was reacted with the 2-[((2-[(5-bromo-2-methylphenyl)amino]-2-oxoethoxy)acetyl)amino]-5-chlorobenzoic acid.methyl ester to give 5-chloro-2-[((2-[(2′-methoxy-4-methylbiphenyl-3-yl)amino]-2-oxoethoxy)acetyl)amino]benzoic acid.methyl ester (yield: 87%).

Sources & evidence

ORD record
ord-2adafdac827547b583bb390accecb384
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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