3-(1H-pyrrol-1-yl)aniline → HCID 44251373, compound

HRID 1964026Notes

Reaction equation

HRID 1964026 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]([CH:10]=[CH:11][CH:12]=2)[NH2:9])[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:28])[CH2:22][O:23][CH2:24][C:25](O)=[O:26])=[C:16]([C:29]([O:31]C)=[O:30])[CH:15]=1>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:28])[CH2:22][O:23][CH2:24][C:25](=[O:26])[NH:9][C:8]2[CH:10]=[CH:11][CH:12]=[C:6]([N:1]3[CH:2]=[CH:3][CH:4]=[CH:5]3)[CH:7]=2)=[C:16]([CH:15]=1)[C:29]([OH:31])=[O:30]

Participants

3

Reactant 2

HCID 27605463-(1H-pyrrol-1-yl)anilineHCID 510399542-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid

Product 1

HCID 44251373HCID 44251373, compound

Procedure

Using the same method as in Example 15-(i), 3-(1H-pyrrol-1-yl)aniline was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 5-chloro-2-([(2-oxo-2-([3-(1H-pyrrol-1-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid.methyl ester (yield: 60%).

Sources & evidence

ORD record
ord-77c930a02dbb49fc87f80751d215b55a
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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