2-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid → HCID 44251304, compound

HRID 1964027Notes

Reaction equation

HRID 1964027 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:6]([C:9]2[CH:13]=[CH:12][O:11][CH:10]=2)=[CH:5][C:3]=1[NH2:4].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:29])[CH2:23][O:24][CH2:25][C:26](O)=[O:27])=[C:17]([C:30]([O:32]C)=[O:31])[CH:16]=1>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:29])[CH2:23][O:24][CH2:25][C:26]([NH:4][C:3]2[CH:5]=[C:6]([C:9]3[CH:13]=[CH:12][O:11][CH:10]=3)[CH:7]=[CH:8][C:2]=2[F:1])=[O:27])=[C:17]([CH:16]=1)[C:30]([OH:32])=[O:31]

Participants

3

Reactant 2

HCID 510399542-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acidHCID 66877424HCID 66877424, compound

Product 1

HCID 44251304HCID 44251304, compound

Procedure

Using the same method as in Example 15-(i), 2-fluoro-5-(furan-3-yl)aniline was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 5-chloro-2-([(2-([2-fluoro-5-(furan-3-yl)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid.methyl ester (yield: 87%).

Sources & evidence

ORD record
ord-6e5eef73573d40f88c2765473a8ced5a
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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