2-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid → HCID 44251303, compound

HRID 1964029Notes

Reaction equation

HRID 1964029 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]1[CH:13]=[CH:12][O:11][CH:10]=1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:29])[CH2:23][O:24][CH2:25][C:26](O)=[O:27])=[C:17]([C:30]([O:32]C)=[O:31])[CH:16]=1>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:29])[CH2:23][O:24][CH2:25][C:26]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([F:1])=[C:3]([C:9]3[CH:13]=[CH:12][O:11][CH:10]=3)[CH:4]=2)=[O:27])=[C:17]([CH:16]=1)[C:30]([OH:32])=[O:31]

Participants

3

Reactant 2

HCID 510399542-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acidHCID 66878166HCID 66878166, compound

Product 1

HCID 44251303HCID 44251303, compound

Procedure

Using the same method as in Example 15-(i), 4-fluoro-3-(furan-3-yl)aniline was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 5-chloro-2-([(2-([4-fluoro-3-(furan-3-yl)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid.methyl ester (yield: 52%).

Sources & evidence

ORD record
ord-d6141fbe3cef4c499b01c0c0a826c5bc
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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