Hydrochloric Acid → HCID 66877163, compound

Participants

Reaction Steps

0.85 g (4.18 mmol) of 2-(3-nitrobenzyl)furan, 1.21 g (21.8 mmol) of reduced iron, and 1 mL of 1N hydrochloric acid were heated under reflux in 10 mL of ethanol for 3.5 hours. After cooling the reaction solution, an aqueous sodium bicarbonate solution was added to alkalify the reaction solution; and filtration through a glass filter, which was covered by celite, was conducted. The filtrate was condensed, and the resulting product was separated and purified using silica gel column chromatography, thereby giving 0.72 g of 3-(furan-2-ylmethyl)aniline (yield: 99%).

Provenance & Evidence