3,5-Dimethylisoxazole-4-boronic acid pinacol ester → HCID 86653351, compound

HRID 1964046Notes

Reaction equation

HRID 1964046 reaction equation
[CH3:1][C:2]1[C:6](B2OC(C)(C)C(C)(C)O2)=[C:5]([CH3:16])[O:4][N:3]=1.I[C:18]1[CH:19]=[C:20]([NH:24][C:25](=[O:27])[OH:26])[CH:21]=[CH:22][CH:23]=1>>[CH3:1][C:2]1[C:6]([C:18]2[CH:19]=[C:20]([NH:24][C:25](=[O:26])[OH:27])[CH:21]=[CH:22][CH:23]=2)=[C:5]([CH3:16])[O:4][N:3]=1

Participants

3

Reactant 2

HCID 27586563,5-Dimethylisoxazole-4-boronic acid pinacol esterHCID 20532501HCID 20532501, compound

Product 1

HCID 86653351HCID 86653351, compound

Procedure

Using the same method as in Example 5-(i), 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole was reacted with the (3-iodophenyl)carbamic acid.tert-butyl to give [3-(3,5-dimethylisoxazol-4-yl)phenyl]carbamic acid.tert-butyl (yield: 85%).

Sources & evidence

ORD record
ord-5da5fbaaa38545ffa1913a574ef2183e
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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