3-(Thiophen-2-yl)aniline → 5-Chloro-2-([(2-oxo-2-([3-(thiophen-2-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid

HRID 1964048Notes

Reaction equation

HRID 1964048 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[C:8]([CH:10]=[CH:11][CH:12]=1)[NH2:9].[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:28])[CH2:22][O:23][CH2:24][C:25](O)=[O:26])=[C:16]([C:29]([O:31]C)=[O:30])[CH:15]=1>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:28])[CH2:22][O:23][CH2:24][C:25](=[O:26])[NH:9][C:8]2[CH:10]=[CH:11][CH:12]=[C:6]([C:2]3[S:1][CH:5]=[CH:4][CH:3]=3)[CH:7]=2)=[C:16]([CH:15]=1)[C:29]([OH:31])=[O:30]

Participants

3

Reactant 2

HCID 27946813-(Thiophen-2-yl)anilineHCID 510399542-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid

Product 1

HCID 442504925-Chloro-2-([(2-oxo-2-([3-(thiophen-2-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid

Procedure

Using the same method as in Example 1-(ii), 3-(thiophen-2-yl)aniline was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 5-chloro-2-([(2-oxo-2-([3-(thiophen-2-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid.methyl ester (yield: 69%).

Sources & evidence

ORD record
ord-8133a5a30ddf4cddb6ff900a4cefec5f
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

Loading…