2-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid → 5-Chloro-2-([(2-([3-(furan-2-ylmethoxy)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid
Reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][O:7][C:8]1[CH:9]=[C:10]([CH:12]=[CH:13][CH:14]=1)[NH2:11].[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:30])[CH2:24][O:25][CH2:26][C:27](O)=[O:28])=[C:18]([C:31]([O:33]C)=[O:32])[CH:17]=1>>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:30])[CH2:24][O:25][CH2:26][C:27]([NH:11][C:10]2[CH:12]=[CH:13][CH:14]=[C:8]([O:7][CH2:6][C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)[CH:9]=2)=[O:28])=[C:18]([CH:17]=1)[C:31]([OH:33])=[O:32]Participants
3
Procedure
Using the same method as in Example 1-(ii), 3-(furan-2-ylmethoxy)aniline was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 5-chloro-2-([(2-([3-(furan-2-ylmethoxy)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid.methyl ester (yield: 66%).
Sources & evidence
- ORD record
- ord-8d57d5429fcc4a3c880d8fb367700c60
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08415479B2
Reaction notes
Loading…