HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid → 5-chloro-2-([(2-oxo-2-([3-(1H-pyrazol-4-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid | HCID 51039954 | — |
| Reactant | 3-(1H-pyrazol-4-yl)aniline | HCID 63338282 | — |
| Product | 5-chloro-2-([(2-oxo-2-([3-(1H-pyrazol-4-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid | HCID 44250426 | — |
Reaction Steps
Using the same method as in Example 1-(ii), 3-(1H-pyrazol-4-yl)aniline was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 5-chloro-2-([(2-oxo-2-([3-(1H-pyrazol-4-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid.methyl ester (yield: 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415479B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-5eecea499ef04c48afb1128ae126c73f |
| Source note | uspto-grants-2013_04 |