3-(1,2-Oxazol-5-yl)aniline → 5-Chloro-2-([(2-([3-(isoxazol-5-yl)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid

HRID 1964062Notes

Reaction equation

HRID 1964062 reaction equation
[O:1]1[C:5]([C:6]2[CH:7]=[C:8]([CH:10]=[CH:11][CH:12]=2)[NH2:9])=[CH:4][CH:3]=[N:2]1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:28])[CH2:22][O:23][CH2:24][C:25](O)=[O:26])=[C:16]([C:29]([O:31]C)=[O:30])[CH:15]=1>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:28])[CH2:22][O:23][CH2:24][C:25]([NH:9][C:8]2[CH:10]=[CH:11][CH:12]=[C:6]([C:5]3[O:1][N:2]=[CH:3][CH:4]=3)[CH:7]=2)=[O:26])=[C:16]([CH:15]=1)[C:29]([OH:31])=[O:30]

Participants

3

Reactant 2

HCID 166406383-(1,2-Oxazol-5-yl)anilineHCID 510399542-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid

Product 1

HCID 442505525-Chloro-2-([(2-([3-(isoxazol-5-yl)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid

Procedure

Using the same method as in Example 15-(i), 3-(isoxazol-5-yl)aniline was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 5-chloro-2-([(2-([3-(isoxazol-5-yl)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid.methyl ester (yield: 56%).

Sources & evidence

ORD record
ord-552307e7640c4ff0ad29ae20eb984bd3
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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