Benzenemethanamine, 3-bromo- → HCID 86653355, compound

HRID 1964063Notes

Reaction equation

HRID 1964063 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH2:6].[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:25])[CH2:19][O:20][CH2:21][C:22](O)=[O:23])=[C:13]([C:26]([O:28]C)=[O:27])[CH:12]=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH:6][C:22](=[O:23])[CH2:21][O:20][CH2:19][C:18]([NH:17][C:14]1[CH:15]=[CH:16][C:11]([Cl:10])=[CH:12][C:13]=1[C:26]([OH:28])=[O:27])=[O:25]

Participants

3

Reactant 2

HCID 457587Benzenemethanamine, 3-bromo-HCID 510399542-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid

Product 1

HCID 86653355HCID 86653355, compound

Procedure

Using the same method as in Example 15-(i), 3-bromobenzylamine was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 2-[((2-[(3-bromobenzyl)amino]-2-oxoethoxy)acetyl)amino]-5-chlorobenzoic acid.methyl ester (yield: 78%).

Sources & evidence

ORD record
ord-85825e05e8b642e5a15ed733619a21f0
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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