Thiophene-3-boronic acid → HCID 44250553, compound

HRID 1964064Notes

Reaction equation

HRID 1964064 reaction equation
[S:1]1[CH:5]=[CH:4][C:3](B(O)O)=[CH:2]1.C[O:10][C:11](=[O:36])[C:12]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=1[NH:19][C:20](=[O:35])[CH2:21][O:22][CH2:23][C:24]([NH:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[C:30](Br)[CH:29]=1)=[O:25]>>[Cl:18][C:16]1[CH:15]=[CH:14][C:13]([NH:19][C:20](=[O:35])[CH2:21][O:22][CH2:23][C:24](=[O:25])[NH:26][CH2:27][C:28]2[CH:29]=[CH:30][CH:31]=[C:32]([C:3]3[CH:4]=[CH:5][S:1][CH:2]=3)[CH:33]=2)=[C:12]([CH:17]=1)[C:11]([OH:36])=[O:10]

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 66877816HCID 66877816, compound

Product 1

HCID 44250553HCID 44250553, compound

Procedure

Using the same method as in Example 19-(ii), 3-thiopheneboronic acid was reacted with the 2-[((2-[(3-bromobenzyl)amino]-2-oxoethoxy)acetyl)amino]-5-chlorobenzoic acid methyl ester to give 5-chloro-2-([(2-oxo-2-([3-(thiophene-3-yl)benzyl]amino)ethoxy)acetyl]amino)benzoic acid.methyl ester (yield: 77%).

Sources & evidence

ORD record
ord-73da2210bc1b4854871516561b4164c3
Source dataset
uspto-grants-2013_04
Patent number
US08415479B2

Reaction notes

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