Epichlorohydrin → HCID 66723969, compound

Participants

Reaction Steps

To a four-necked flask equipped with a thermometer, a dropping funnel, a cooling tube, and a stirrer was charged with 610.6 g (6.6 mol) of epichlorohydrin, and then the inside of the four-necked flask was purged with nitrogen. In 1018.5 g of ethanol was dissolved 203.7 g (1.1 mol) of 4-phenoxyaniline powder. The temperature of the epichlorohydrin was raised to 70° C. and the ethanolic solution of 4-phenoxyaniline was dropped over 4 hours. Moreover, the reaction was continued at 70° C. for six hours under stirring to produce 4-phenoxy-N,N-bis(2-hydroxy-3-chloropropyl)aniline.

Provenance & Evidence