HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-beta-aminophenethyl alcohol → 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-[(1R)-2-hydroxy-1-phenylethyl]-1,3-thiazolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-beta-aminophenethyl alcohol | HCID 2724025 | — |
| Reactant | 3-(Biphenyl-4-ylsulfonyl)-1,3-thiazolidine-2-carboxylic acid | HCID 57423221 | — |
| Product | 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-[(1R)-2-hydroxy-1-phenylethyl]-1,3-thiazolidine-2-carboxamide | HCID 60036765 | — |
Reaction Steps
Following the general strategies and protocols outlined in Example 1, starting from 3-([1,1′-biphenyl]-4-ylsulfonyl)-1,3-thiazolidine-2-carboxylic acid (Intermediate 8) and commercial (2R)-2-amino-2-phenylethanol, the title compound was obtained in 98% purity by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415480B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-533c205a527f47fbb7487a698f5b2f35 |
| Source note | uspto-grants-2013_04 |