HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-3-(4-fluorophenyl)propan-1-ol → 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-[1-(4-fluorophenyl)-3-hydroxypropyl]-1,3-thiazolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-3-(4-fluorophenyl)propan-1-ol | HCID 22115252 | — |
| Reactant | 3-(Biphenyl-4-ylsulfonyl)-1,3-thiazolidine-2-carboxylic acid | HCID 57423221 | — |
| Product | 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-[1-(4-fluorophenyl)-3-hydroxypropyl]-1,3-thiazolidine-2-carboxamide | HCID 60036781 | — |
Reaction Steps
Following the general strategies and protocols outlined in Example 1, starting from 3-([1,1′-biphenyl]-4-ylsulfonyl)-1,3-thiazolidine-2-carboxylic acid (Intermediate 8) and 3-amino-3-(4-fluorophenyl)-1-propanol (Intermediate 2), the title compound was obtained in 92% purity by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415480B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-4f3c9cc25ff44708926cf7e2d801532a |
| Source note | uspto-grants-2013_04 |