3-Amino-3-(1,3-benzodioxol-5-yl)-1-propanol → HCID 60036804, compound

HRID 1964815Notes

Reaction equation

HRID 1964815 reaction equation
[C:1]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:6]=[CH:5][C:4]([S:7]([N:10]2[CH2:14][CH2:13][S:12][CH:11]2[C:15](O)=[O:16])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[NH2:24][CH:25]([C:29]1[CH:37]=[CH:36][C:32]2[O:33][CH2:34][O:35][C:31]=2[CH:30]=1)[CH2:26][CH2:27][OH:28]>>[O:33]1[C:32]2[CH:36]=[CH:37][C:29]([CH:25]([NH:24][C:15]([CH:11]3[N:10]([S:7]([C:4]4[CH:5]=[CH:6][C:1]([C:18]5[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=5)=[CH:2][CH:3]=4)(=[O:8])=[O:9])[CH2:14][CH2:13][S:12]3)=[O:16])[CH2:26][CH2:27][OH:28])=[CH:30][C:31]=2[O:35][CH2:34]1

Participants

3

Reactant 2

HCID 37983233-Amino-3-(1,3-benzodioxol-5-yl)-1-propanol2×HCID 574232213-(Biphenyl-4-ylsulfonyl)-1,3-thiazolidine-2-carboxylic acid2×

Product 1

HCID 60036804HCID 60036804, compound

Procedure

Following the general strategies and protocols outlined in Example 1, starting from 3-([1,1′-biphenyl]-4-ylsulfonyl)-1,3-thiazolidine-2-carboxylic acid (Intermediate 8) and 3-amino-3-(1,3-benzodioxol-5-yl)-1-propanol (Intermediate 2), the title compound was obtained in 92% purity by HPLC.

Sources & evidence

ORD record
ord-9db1091158b54f66ad0e91b4a6253071
Source dataset
uspto-grants-2013_04
Patent number
US08415480B2

Reaction notes

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