HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sarcosine methyl ester → methyl [[(3S)-3-({[(2S)-3-([1,1'-biphenyl]-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}amino)-3-phenylpropyl](methyl)amino]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sarcosine methyl ester | HCID 83545 | — |
| Reactant | (3S)-3-({[(2S)-3-([1,1'-biphenyl]-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}amino)-3-phenylpropyl methanesulfonate | HCID 60036776 | — |
| Product | methyl [[(3S)-3-({[(2S)-3-([1,1'-biphenyl]-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}amino)-3-phenylpropyl](methyl)amino]acetate | HCID 60036806 | — |
Reaction Steps
Following the general method A as outlined in Example 16, starting from (3S)-3-({[(2S)-3-([1,1′-biphenyl]-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}amino)-3-phenylpropyl methanesulfonate (Intermediate 9) and methyl(methylamino)acetate, the title compound was obtained in 98.9% purity by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415480B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-e3fd1710b830466f9372c45d78c40809 |
| Source note | uspto-grants-2013_04 |