HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-[1-phenyl-3-(1-pyrrolidinyl)propyl]-1,3-thiazolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | (3S)-3-({[(2S)-3-([1,1'-biphenyl]-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}amino)-3-phenylpropyl methanesulfonate | HCID 60036776 | — |
| Product | 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-[1-phenyl-3-(1-pyrrolidinyl)propyl]-1,3-thiazolidine-2-carboxamide | HCID 60036757 | — |
Reaction Steps
Following the general method A as outlined in Example 16, starting from 3-({[3-([1,1′-biphenyl]-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}amino)-3-phenylpropyl methanesulfonate (Intermediate 9) and pyrrolidine, the title compound was obtained in 99.2% purity by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415480B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-69d2325f003943fc8a19068628188f00 |
| Source note | uspto-grants-2013_04 |