HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-[3-(4-morpholinyl)-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | (3S)-3-({[(2S)-3-([1,1'-biphenyl]-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}amino)-3-phenylpropyl methanesulfonate | HCID 60036776 | — |
| Product | 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-[3-(4-morpholinyl)-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide | HCID 60036815 | — |
Reaction Steps
Following the general method A as outlined in Example 16, starting from 3-({[3-([1,1′-biphenyl]-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}amino)-3-phenylpropyl methanesulfonate (Intermediate 9) and morpholine, the title compound was obtained in 99.3% purity by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415480B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-fe3e653c5ec24bbabf121681351c7066 |
| Source note | uspto-grants-2013_04 |