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4-Fluorobenzylamine → 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-(4-fluorobenzyl)-1,3-thiazolidine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorobenzylamine | HCID 67326 | — |
| 反応物 | (1,1'-Biphenyl)-4-sulphonyl chloride | HCID 74192 | — |
| 反応物 | 3-(tert-Butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acid | HCID 4644094 | — |
| 反応物 | Benzophenone, 4-nitro-, oxime | HCID 6506582 | — |
| 生成物 | 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-(4-fluorobenzyl)-1,3-thiazolidine-2-carboxamide | HCID 60036784 | — |
反応手順
Following the general solid phase method as outlined Example 33, starting from 3-(tert-butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acid, Kaiser oxime resin, 1,1′-biphenyl-4-sulfonyl chloride and (4-fluorophenyl)methanamine, the title compound was obtained in 92% purity by HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08415480B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-47a87ba376cf49ffa7cec4dc2e3b1c72 |
| 出典メモ | uspto-grants-2013_04 |