HRID1964833

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7036

Benzhydrylamine

C13H13N

HCID74192

(1,1'-Biphenyl)-4-sulphonyl chloride

C12H9ClO2S

HCID4644094

3-(tert-Butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acid

C9H15NO4S

$结构：O=[N+]([O-])c1ccc(/C(=N\O)c2ccccc2)cc1$

HCID6506582

未命名化合物

PRODUCTS

生成物

结构：O=C(NC(c1ccccc1)c1ccccc1)C1SCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1

HCID10311490

未命名化合物

PROCEDURE

实验过程

Following the general solid phase method as outlined Example 33, starting from 3-(tert-butoxy-carbonyl)-1,3-thiazolidine-2-carboxylic acid, Kaiser oxime resin, 1,1′-biphenyl-4-sulfonyl chloride and benzhydrylamine, the title compound was obtained in 98.5% purity by HPLC.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ad7fb46b62bd432a96d0fea982e55e96
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08415480B2
来源说明: uspto-grants-2013_04

反应 SMILES

C(OC([N:8]1[CH2:12][CH2:11][S:10][CH:9]1[C:13]([OH:15])=O)=O)(C)(C)C.[CH:16]1[CH:21]=[CH:20][C:19](/[C:22](/[C:25]2[CH:30]=[CH:29][C:28]([N+]([O-])=O)=[CH:27][CH:26]=2)=[N:23]/O)=[CH:18][CH:17]=1.[C:34]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH:39]=[CH:38][C:37]([S:40](Cl)(=[O:42])=[O:41])=[CH:36][CH:35]=1.C(N)(C1C=CC=CC=1)C1C=CC=CC=1>>[CH:22]([NH:23][C:13]([CH:9]1[N:8]([S:40]([C:37]2[CH:36]=[CH:35][C:34]([C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)=[CH:39][CH:38]=2)(=[O:42])=[O:41])[CH2:12][CH2:11][S:10]1)=[O:15])([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:19]1[CH:20]=[CH:21][CH:16]=[CH:17][CH:18]=1