(1,1'-Biphenyl)-4-sulphonyl chloride → HCID 10217272, compound

HRID 1964836Notes

Reaction equation

HRID 1964836 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][S:10][CH:9]1[C:13]([OH:15])=O)=O)(C)(C)C.C1C=CC(/C(/C2C=CC([N+]([O-])=O)=CC=2)=N/O)=CC=1.[C:34]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH:39]=[CH:38][C:37]([S:40](Cl)(=[O:42])=[O:41])=[CH:36][CH:35]=1.[CH3:50][O:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][C:53]=1[CH2:58][NH2:59]>>[C:34]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH:39]=[CH:38][C:37]([S:40]([N:8]2[CH2:12][CH2:11][S:10][CH:9]2[C:13]([NH:59][CH2:58][C:53]2[CH:54]=[CH:55][CH:56]=[CH:57][C:52]=2[O:51][CH3:50])=[O:15])(=[O:42])=[O:41])=[CH:36][CH:35]=1

Participants

5

Reactant 4

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 812922-MethoxybenzylamineHCID 46440943-(tert-Butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acidHCID 6506582Benzophenone, 4-nitro-, oxime

Product 1

HCID 10217272HCID 10217272, compound

Procedure

Following the general solid phase method as outlined Example 33, starting from 3-(tert-butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acid, Kaiser oxime resin, 1,1′-biphenyl-4-sulfonyl chloride and (2-methoxyphenyl)methanamine, the title compound was obtained in 98.5% purity by HPLC.

Sources & evidence

ORD record
ord-8976a16c038c41dfac9484d87bf8ff40
Source dataset
uspto-grants-2013_04
Patent number
US08415480B2

Reaction notes

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