(1,1'-Biphenyl)-4-sulphonyl chloride → HCID 10152528, compound

HRID 1964846Notes

Reaction equation

HRID 1964846 reaction equation
[C:1]1([C@@H:7]([NH:14][C:15]([C@H:17]2[N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19][S:18]2)=[O:16])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:29]1([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH:34]=[CH:33][C:32]([S:35](Cl)(=[O:37])=[O:36])=[CH:31][CH:30]=1>>[C:29]1([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH:34]=[CH:33][C:32]([S:35]([N:21]2[CH2:20][CH2:19][S:18][C@H:17]2[C:15]([NH:14][C@H:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)=[O:16])(=[O:37])=[O:36])=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 60036801HCID 60036801, compound2×

Product 1

HCID 10152528HCID 10152528, compound

Procedure

Following the general strategies and protocols outlined in Example 1, starting from tert-butyl (2S)-2-({[(R)-phenyl(pyridin-2-yl)methyl]amino}-carbonyl)-1,3-thiazolidine-3-carboxylate (Intermediate 6) and [1,1′-biphenyl]-4-sulfonyl chloride, the title compound was obtained in 99% purity by HPLC.

Sources & evidence

ORD record
ord-560db8ea80794663b97d0a69ad95e9cc
Source dataset
uspto-grants-2013_04
Patent number
US08415480B2

Reaction notes

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