HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-1H-pyrrolo[2,3-b]pyridine → Thiophene-2-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-1H-pyrrolo[2,3-b]pyridine | HCID 24229213 | — |
| Reactant | N-(2,4-difluoro-3-formylphenyl)propane-2-sulfonamide | HCID 58086031 | — |
| Reactant | Thiophene-2-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide | HCID 58086492 | — |
| Product | Thiophene-2-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide | HCID 58086197 | — |
Reaction Steps
was prepared using the protocol of Steps 3 and 4 of Scheme 17, substituting 5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin 89 with 5-chloro-7-azaindole 80 (see Example 9) and propane-2-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide 60 with thiophene-2-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide 512 (see Example 21) in Step 3. MS(ESI) [M+H+]−=451.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415469B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-c90216ab19414a6f9f40cdc5df1f8dc0 |
| Source note | uspto-grants-2013_04 |