1H-Indazole → HCID 58087154, compound

HRID 1964905Notes

Reaction equation

HRID 1964905 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([F:18])=[C:11]([C:14]([F:17])=[CH:15][CH:16]=1)[CH:12]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]2[CH:26]=[C:27]3[CH:33]=[CH:32][NH:31][C:28]3=[N:29][CH:30]=2)[CH:20]=1.N1C2C(=CC=CC=2)C=N1>>[CH2:1]([O:8][C:9]1[C:10]([F:18])=[C:11]([C:14]([F:17])=[CH:15][CH:16]=1)[CH2:12][C:33]1[C:27]2[C:28](=[N:29][CH:30]=[C:25]([C:21]3[CH:20]=[N:19][CH:24]=[CH:23][CH:22]=3)[CH:26]=2)[NH:31][CH:32]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 92211H-IndazoleHCID 5613532,6-Difluoro-3-(phenylmethoxy)benzaldehydeHCID 513585515-(Pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 58087154HCID 58087154, compound

Procedure

Additional compounds were prepared following steps 3 and 4 of Scheme 43a, replacing 3-benzyloxy-2,6-difluoro-benzaldehyde 526 with an appropriate aldehyde and/or pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine 89 with an appropriate azaindole (see Example 9 or Example 16) in Step 3. The following compounds were made following this procedure:

Workup

  1. customAdditional compounds were prepared

Sources & evidence

ORD record
ord-a07d9ae591954fd095d2a34fe26c8721
Source dataset
uspto-grants-2013_04
Patent number
US08415469B2

Reaction notes

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