Methanol → HCID 58086875, compound

HRID 1964918Notes

Reaction equation

HRID 1964918 reaction equation
[OH-].[K+].[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[CH:5]=[CH:4]1.[CH2:12]([O:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]=[O:25])=[CH:22][C:21]=1[O:28][CH3:29])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[CH3:30]O>>[CH2:12]([O:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]([O:25][CH3:30])[C:5]2[C:6]3[C:11](=[N:10][CH:9]=[CH:8][CH:7]=3)[NH:3][CH:4]=2)=[CH:22][C:21]=1[O:28][CH3:29])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

5

Reactant 4

HCID 887MethanolHCID 92221H-Pyrrolo(2,3-b)pyridineHCID 14797Potassium HydroxideHCID 755064-(Benzyloxy)-3-methoxybenzaldehyde

Product 1

HCID 58086875HCID 58086875, compound

Procedure

Methanol (125 mL) and potassium hydroxide (4.4 g, 79 mmol) were mixed with 1H-pyrrolo[2,3-b]pyridine (94, 3.1 g, 26.6 mmol) and 4-benzyloxy-3-methoxy-benzaldehyde (564, 12.9 g, 53.2 mmol). The reaction was stirred at room temperature for 2 days. The resulting white solid was filtered and washed with water. Crude material was carried forward without further purification.

Workup

  1. filtrationThe resulting white solid was filtered
  2. washwashed with water
  3. customCrude material was carried forward without further purification

Sources & evidence

ORD record
ord-de6090966618423a992c4905e0a781c6
Source dataset
uspto-grants-2013_04
Patent number
US08415469B2

Reaction notes

Loading…