Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-Pyrrolo(2,3-b)pyridine → 3-[3-(4-chloro-benzyloxy)-2-ethoxy-benzyl]1H-pyrrolo[2,3-b]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-Pyrrolo(2,3-b)pyridine | HCID 9222 | — |
| 반응물 | 1,1,1-Trifluoro-2-iodoethane | HCID 67709 | — |
| 반응물 | 4-Chloro-2-fluorobenzyl bromide | HCID 2736551 | — |
| 반응물 | Oxazole, 4,5-dihydro-4-ethyl-2-((4-methoxyphenyl)methyl)-, (+-)- | HCID 3041214 | — |
| 반응물 | 5-methoxy-1H-pyrrolo[2,3-b]pyridine | HCID 10307871 | — |
| 반응물 | [3-(4-chloro-2-fluoro-benzyloxy)-2-ethoxy-phenyl]-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone | HCID 58086972 | — |
| 생성물 | 3-[3-(4-chloro-benzyloxy)-2-ethoxy-benzyl]1H-pyrrolo[2,3-b]pyridine | HCID 58087711 | — |
반응 단계
were prepared following the protocol of Scheme 71, substituting iodoethane with iodomethane in Step 3 to provide P-1891, or substituting iodoethane with 2-iodo-1,1,1-trifluoroethane in Step 3 to provide P-2076, or substituting 4-chlorobenzyl bromide 557 with 4-chloro-2-fluoro-benzyl bromide in Step 1 and 7-azaindole 94 with 5-methoxy-7-azaindole in Step 4 to provide P-2016. MS(ESI) [M+H+]+=393.4 (P-1891), 461.08 (P-2076), and 455.2 (P-2016).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08415469B2 |
| 출처 데이터셋 | uspto-grants-2013_04 |
| ORD ID | ord-719c9062d7554d7d8a61bc71af41d6af |
| 출처 메모 | uspto-grants-2013_04 |