HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1964990Generated: October 31, 2026
Tris(1,1-dimethylethyl)phosphine → HCID 66679380, compound
https://huagongshe.com/reaction/1964990
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | Benzo[b]furan-2-boronic acid | HCID 2776266 | — |
| Reactant | 4-Chloro-1H-pyrrolo[2,3-b]pyridine | HCID 11389493 | — |
| Catalyst | Palladium, tris[mu-[(1,2-eta:4,5-eta)-(1E,4E)-1,5-diphenyl-1,4-pentadien-3-one]]di-, compd. with trichloromethane (1:1) | HCID 11029508 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 66679380 | HCID 66679380 | — |
Reaction Steps
4-Chloro-7-azaindole (119, 100 mg, 0.66 mmol, prepared as described in Example 70, Scheme 81), 2-Benzofuranboronic acid (212 mg, 1.31 mmol) and Potassium fluoride (127 mg, 2.18 mmol) were stirred in 3 mL of anhydrous dioxane. Tris(dibenzylideneacetone)dipalladium(0) chloroform adduct (10.2 mg, 9.83E-3 mmol) and tri t-butylphosphine (6.6 mg, 0.033 mol) were added and the suspension was stirred at 100° C. for 4 hours in a pressure tube under inert atmosphere. The reaction mixture was cooled to room temperature and was adsorbed onto silica gel and purified by chromatography to provide the compound (120, 56 mg, 36%). MS(ESI) [M+H+]+=235.20.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08415469B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-cf0057a317194e7c97f8116c5027cb01 |
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| Source note | uspto-grants-2013_04 |
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