HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-5-nitrobenzoic acid → 3-Amino-5-fluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-5-nitrobenzoic acid | HCID 2759047 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Amino-5-fluorobenzoic acid | HCID 17915148 | — |
Reaction Steps
Into a Parr pressure reactor were added 3-fluoro-5-nitrobenzoic acid (667, 5.0 g, 0.027 mol), methanol (50.0 mL), 20% Pd(OH)2 on carbon (300 mg). The reaction was shaken under an atmosphere of hydrogen at 50 psi overnight. The reaction was filtered through celite and was concentrated to dryness to provide a white solid (668, 4.0 g, 95.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415469B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-1661dd23c119417895773b0e4225ec15 |
| Source note | uspto-grants-2013_04 |