HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-Fluoro-5-(propane-1-sulfonylamino)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-Fluoro-5-(propylsulfonamido)benzoic acid | HCID 58086694 | — |
| Product | 2-Fluoro-5-(propane-1-sulfonylamino)-benzoic acid methyl ester | HCID 59506865 | — |
Reaction Steps
To 2-Fluoro-5-(propane-1-sulfonylamino)-benzoic acid (669, 2.0 g, 0.0076 mol) in methanol (20.0 mL) was added sulfuric acid (0.90 mL, 0.017 mol). The reaction was stirred at room temperature overnight. The reaction was concentrated and purified with silica gel column chromatograph eluting with 20% ethyl acetate in hexane to give a white solid (670, 1.27 g, 62%). MS (ESI) [M−H+]−=274.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415469B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-c4a250ad1fea4400bf34cd79a1a9b925 |
| Source note | uspto-grants-2013_04 |