Ammonia → HCID 67979438, compound

Participants

Reaction Conditions

Reaction Steps

6″-Bromo-5′″-methyl-3″H-trispiro[1,3-dioxolane-2,1′-cyclohexane-4′,2″-indene-1″,2′″-imidazole]-4″(3′″H)-thione (Example 115 Step 4, 0.5 g, 1.19 mmol) was taken up in ammonia (7 M in MeOH, 15 mL, 105 mmol) and the resulting mixture was heated in the microwave reactor at 110° C. for 30 min. The solvent was evaporated in vacuo and the same procedure (addition of ammonia, heating and evaporation) was repeated 3 times. The solvent was evaporated to yield the title compound (0.568 g, quantitative yield) that was used without further purification: 1H NMR (500 MHz, CDCl3) δ ppm 1.35-1.49 (m, 2 H), 1.61 (d, 2 H), 1.69-1.81 (m, 2 H), 2.33 (s, 3 H), 3.14 (s, 2 H), 3.87-3.98 (m, 4 H), 6.88 (d, 1 H), 7.19 (d, 1 H), 7.35 (dd, 1 H); MS (ES+) m/z 404 [M+H]+.

Provenance & Evidence