HCID 67506196, compound → HCID 67607035, compound

HRID 1965195Notes

Reaction equation

HRID 1965195 reaction equation
C(OC([N:11]1[CH2:15][CH2:14][CH:13]2[N:16]([C:20](=[O:25])[NH:21][CH:22]([CH3:24])[CH3:23])[CH2:17][CH:18]([OH:19])[CH:12]12)=O)C1C=CC=CC=1>CO>[CH:22]([NH:21][C:20]([N:16]1[CH2:17][CH:18]([OH:19])[CH:12]2[NH:11][CH2:15][CH2:14][CH:13]12)=[O:25])([CH3:24])[CH3:23]

Participants

3

Reactant 1

HCID 67506196HCID 67506196, compound

Product 1

HCID 67607035HCID 67607035, compoundYield 117.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture containing crude 53 (˜6.2 g, 17.9 mmol) and 10% Pd-on-carbon (wet, 1.9 g, 1.8 mmol) in MeOH (200 mL) was stirred vigorously under an atmosphere of H2. After 3 h, the catalyst was removed by filtration and the filtrate was concentrated in vacuo to afford 4.5 g of 54 as a colorless oil which was used without further purification.

Workup

  1. customthe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-3c669e02c2c44cb4a1483e07c6762b2a
Source dataset
uspto-grants-2013_04
Patent number
US08415486B2

Reaction notes

Loading…