HCID 67606455, compound → HCID 67609205, compound

HRID 1965197Notes

Reaction equation

HRID 1965197 reaction equation
C(OC(=O)[NH:10][CH:11]([C:16]([N:18]1[CH2:22][CH2:21][CH:20]2[N:23]([C:27](=[O:32])[NH:28][CH:29]([CH3:31])[CH3:30])[CH2:24][CH:25]([OH:26])[CH:19]12)=[O:17])[C:12]([CH3:15])([CH3:14])[CH3:13])C1C=CC=CC=1>CO>[CH:29]([NH:28][C:27]([N:23]1[CH2:24][CH:25]([OH:26])[CH:19]2[N:18]([C:16](=[O:17])[CH:11]([NH2:10])[C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:22][CH2:21][CH:20]12)=[O:32])([CH3:31])[CH3:30]

Participants

3

Reactant 1

HCID 67606455HCID 67606455, compound

Product 1

HCID 67609205HCID 67609205, compoundYield 119.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture containing 55 (7.2 g, 15.6 mmol) and 10% Pd-on-carbon (wet, 1.7 g, 1.5 mmol) in MeOH (200 mL) were stirred vigorously under an atmosphere of H2. After 2 h, the was removed by filtration and the filtrate was diluted with toluene and concentrated in vacuo to afford 6.1 g of 56 as an off-white-colored foam which was used without further purification. Mass spectrum, m/z [326.7] (M+H)+.

Workup

  1. customthe was removed by filtration
  2. additionthe filtrate was diluted with toluene
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-0daa4b423fec4988b3132824cd036339
Source dataset
uspto-grants-2013_04
Patent number
US08415486B2

Reaction notes

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