2,3-dihydro-6H-[1,4]dioxino[2,3-f]indole-7,8-dione → HCID 68598719, compound

HRID 1965352Notes

Reaction equation

HRID 1965352 reaction equation
[O:1]1[C:6]2=[CH:7][C:8]3[C:9](=[O:15])[C:10](=[O:14])[NH:11][C:12]=3[CH:13]=[C:5]2[O:4][CH2:3][CH2:2]1.Br[C:17]1C=CC=C2C=1C(=O)C(=O)N2>>[CH3:17][N:11]1[C:12]2[CH:13]=[C:5]3[O:4][CH2:3][CH2:2][O:1][C:6]3=[CH:7][C:8]=2[C:9](=[O:15])[C:10]1=[O:14]

Participants

3

Reactant 2

HCID 20298022,3-dihydro-6H-[1,4]dioxino[2,3-f]indole-7,8-dioneHCID 45000124-Bromoisatin

Product 1

HCID 68598719HCID 68598719, compound

Procedure

Following the procedure as described in PREPARATION 79A, and making non-critical variations using 2,3-dihydro-6H-[1,4]dioxino[2,3-f]indole-7,8-dione to replace 4-bromoisatin, 6-methyl-2,3-dihydro-6H-[1,4]dioxino[2,3-f]indole-7,8-dione was obtained (68%): 1H NMR (300 MHz, CDCl3) δ 7.09 (s, 1H), 6.74 (s, 1H), 4.41-4.38 (m, 2H), 4.27-4.24 (m, 2H), 3.08 (s, 3H); 13C NMR (75 MHz, CDCl3) δ; MS (ES+) m/z 220.2 (M+1).

Sources & evidence

ORD record
ord-a917939cc0b04896af8567ce35c69e67
Source dataset
uspto-grants-2013_04
Patent number
US08415370B2

Reaction notes

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