Bromodiphenylmethane → HCID 67357421, compound

HRID 1965355Notes

Reaction equation

HRID 1965355 reaction equation
Br[C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4](=[O:12])[C:5](=[O:11])[NH:6]2.O1C2=CC3C(=O)C(=O)NC=3C=C2OCC1.Br[CH:29]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.[Br:42]CC1OC(C(F)(F)F)=CC=1>>[Br:42][C:33]1[CH:34]=[CH:35][C:30]([CH:29]([N:6]2[C:7]3[C:3](=[CH:2][CH:10]=[CH:9][CH:8]=3)[C:4](=[O:12])[C:5]2=[O:11])[C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[CH:31][CH:32]=1

Participants

5

Reactant 4

HCID 236603BromodiphenylmethaneHCID 20298022,3-dihydro-6H-[1,4]dioxino[2,3-f]indole-7,8-dioneHCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 45000124-Bromoisatin

Product 1

HCID 67357421HCID 67357421, compound

Procedure

Following the procedure as described in PREPARATION 26A and making non-critical variations using 4-bromoisatin to replace 2,3-dihydro-6H-[1,4]dioxino[2,3-f]indole-7,8-dione, and bromodiphenylmethane to replace 2-(bromomethyl)-5-(trifluoromethyl)furan, 4-bromo-benzhydrylindoline-2,3-dione was obtained (78%) as a red solid: MS (ES+) m/z 413.8 (M+23), 415.8 (M+23).

Sources & evidence

ORD record
ord-06c887e640c7434f964ce8545046eabe
Source dataset
uspto-grants-2013_04
Patent number
US08415370B2

Reaction notes

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