HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromodiphenylmethane → 1-(diphenylmethyl)-4,6-dimethoxy-1H-indole-2,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromodiphenylmethane | HCID 236603 | — |
| Reactant | 2,3-dihydro-6H-[1,4]dioxino[2,3-f]indole-7,8-dione | HCID 2029802 | — |
| Reactant | 2-(Bromomethyl)-5-(trifluoromethyl)furan | HCID 2794605 | — |
| Reactant | 4,6-dimethoxy-2,3-dihydro-1H-indole-2,3-dione | HCID 11557522 | — |
| Product | 1-(diphenylmethyl)-4,6-dimethoxy-1H-indole-2,3-dione | HCID 67357052 | — |
Reaction Steps
Following the procedure as described in PREPARATION 26A and making non-critical variations using 4,6-dimethoxy-1H-indole-2,3-dione to replace 2,3-dihydro-6H-[1,4]dioxino[2,3-f]indole-7,8-dione, and bromodiphenylmethane to replace 2-(bromomethyl)-5-(trifluoromethyl)furan, 1-(diphenylmethyl)-4,6-dimethoxy-1H-indole-2,3-dione was obtained (90%): 1H NMR (300 MHz, DMSO-d6) δ7.49-7.19 (m, 10H), 6.72 (s, 1H), 6.21 (d, J=1.5 Hz, 1H), 5.87 (d, J=1.5 Hz, 1H), 3.86 (s, 3H), 3.70 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415370B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-1bcb0233d72f431fa02ebf387e73d9b1 |
| Source note | uspto-grants-2013_04 |