HCID 59352467, compound → HCID 59352345, compound

HRID 1965713Notes

Reaction equation

C([N:8]1[CH2:13][CH2:12][O:11][C@H:10]([CH2:14][N:15]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C@@:17]3([C:35]4[C:26](=[CH:27][C:28]5[O:33][CH2:32][CH2:31][O:30][C:29]=5[CH:34]=4)[O:25][CH2:24]3)[C:16]2=[O:36])[CH2:9]1)C1C=CC=CC=1.C(N1CCOC(CN2C3C(=CC=CC=3)C3(C4C(=CC5OCCOC=5C=4)OC3)C2=O)C1)C1C=CC=CC=1>>[NH:8]1[CH2:13][CH2:12][O:11][C@H:10]([CH2:14][N:15]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C@@:17]3([C:35]4[C:26](=[CH:27][C:28]5[O:33][CH2:32][CH2:31][O:30][C:29]=5[CH:34]=4)[O:25][CH2:24]3)[C:16]2=[O:36])[CH2:9]1

Participants

Reactant 2

HCID 59352467HCID 59352467, compound

HCID 67356681HCID 67356681, compound

Product 1

HCID 59352345HCID 59352345, compound

Procedure

Following the procedure described in EXAMPLE 11.102 and making non-critical variations using (8S)-1′-{[(2S)-4-benzylmorpholin-2-yl]methyl}-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3′-indol]-2′(1′H)-one to replace 1′-[(4-benzylmorpholin-2-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3′-indol]-2′(1′H)-one, (8S)-1′-[(2S)-morpholin-2-ylmethyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3′-indol]-2′(1H)-one was obtained (56%): MS (ES+) m/z 395.1 (M+1).

Sources & evidence

ORD record: ord-ce5bc4e1e9fa49b39d3889871ba6bafd
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08415370B2

Reaction notes

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