HCID 67388651, compound → HCID 58444081, compound

Participants

Reaction Steps

21.0 g of crude 4-(4-tert-butyl-phenyl)-2-(1-methyl-cyclo-hexylmethylene)-indan-1-one (GC: ˜83% purity) are dissolved in 220 ml of ethyl acetate in a flask with gas inlet and stirrer. 1.5 g of palladium on activated carbon (10 wt-% palladium) are added. The system is evacuated and refilled with argon three times to remove oxygen and then evacuated and refilled with hydrogen three times. The stirrer is started and the reaction mixture is vigorously stirred to help the diffusion of hydrogen gas into the liquid reaction mixture. The hydrogen uptake is monitored and stirring is continued until the hydrogen uptake ceases. Filtering the crude reaction mixture over a paper filter and removing the solvent in a vacuum leaves crude 4-(4-tert-butyl-phenyl)-2-((1-methylcyclohexyl)methyl)-indan-1-one (yield 19.9 g, GC: ˜86% purity). The obtained crude product was used without further purification for the subsequent reduction/elimination-sequence.

Provenance & Evidence